In play three, Burke abandoned Cristina astatine the altar and past conscionable took off, yet winning a Harper Avery grant elsewhere and past astatine immoderate point, moving to Zurich, Switzerland to unfastened his ain hi-tech hospital. He got married, started a family, and past successful play 10, helium invited Cristina to his infirmary to instrumentality it implicit for him arsenic helium retired. 

Isaiah Washington near the bid aft it was reported that helium called costar T.R. Knight a cheery slur during an statement connected set, and each his defenses conscionable kept making it worse earlier helium yet was fto spell from the series. Apparently helium and ABC made up, due to the fact that they fto him instrumentality for a 2nd successful 2014. His astir important relation since was Thelonious Jaha connected The CW's The 100, until his quality died successful play five, followed by Starz' critically acclaimed P-Valley.

Intern Norman arrived successful play 4 and had to fend disconnected assumptions that helium was an attendant, alternatively than an intern, owed to his age. He messed up and told the incorrect diligent she was dying, and aboriginal helium collapsed and had a stroke. He had country to region the humor clot, and decided aft his country that helium was going to transportation to psych. 

Edward Herrmann, a reasonably legendary actor, is mostly wide known arsenic Richard Gilmore connected Gilmore Girls. He besides appeared successful respective episodes of The Good Wife, Harry's Law, and adjacent American Dad earlier his decease successful 2014. 

Sydney was the perky nonmigratory who took implicit for Bailey during her maternity permission and drove everyone brainsick with her perkiness. She adjacent went connected a day with Derek astatine 1 point, but benignant of disappeared successful aboriginal play four—until now, the play 21 trailer revealing that Dr. Heron is back. 

Kali Rocha astir precocious starred connected Liv and Maddie and Man with a Plan plus a 2024 occurrence of Curb Your Enthusiasm. 

One of the biggest tearjerkers connected this list, astatine the extremity of play five, George had conscionable decided to enlist arsenic a trauma surgeon successful the service and was connected his mode to bash truthful erstwhile helium saved a pistillate from getting deed by a bus, lone to beryllium deed himself. He was successful specified atrocious signifier erstwhile helium got to the infirmary that nary 1 recognized him until helium utilized his digit to constitute his nickname, 007, successful Meredith's hand. They were incapable to prevention him, and helium tragically died. 

After respective tumultuous seasons down the scenes (including Isaiah Washington utilizing the f-word portion allegedly referring to him), Knight struggled with immoderate of George's storylines and the information that George hardly appeared successful the opening of play five, and asked to beryllium released from his contract.

Knight returned to Shondaland successful 2017 for an arc connected The Catch, and has besides appeared connected The Good Wife, 11.22.63, and Genius, among different series. In 2019, helium appeared connected The Bravest Knight and successful 2020, helium appeared successful HBO Max series The Flight Attendant with Kaley Cuoco. He besides returned to Grey's for 1 occurrence to conscionable Meredith during her COVID-19 coma.

Erica Hahn and Callie Torres started a narration that truly whitethorn person gone somewhere, until Erica learned astir the clip Izzie Stevens chopped Denny Duquette's LVAD ligament successful attempts to prevention his life. The bosom that past went to Denny was taken from 1 of Erica's patients. When Callie refused to study the situation, Erica up and near the narration and her occupation successful aboriginal play five. 

Brooke Smith went connected to look successful Bosch, Bates Motel, Supergirl, The Good Doctor, Chicago Med, and The Good Fight, and the 2019 movie Bombshell. 

Izzie Stevens got cancer, joined Alex Karev, survived the cancer, and past sorta conscionable disappeared successful play six. She yet returned for a 2nd and admitted she didn't consciousness similar Seattle was her location anymore. Later, Alex got sent divorcement papers, and present we cognize Izzie secretly had Alex's twins, lives connected a ranch successful Kansas, and became a surgical oncologist. 

Katherine Heigl's exit fundamentally began successful 2008 erstwhile she withdrew her sanction from Emmy information due to the fact that she didn't consciousness similar the worldly deserved it. In 2010, the quality disappeared completely. She said successful the years since that she would similar to instrumentality to the character, but creator Shonda Rhimes did not. "I'm done with that story," she told TVLine successful 2015. 

Heigl, past a burgeoning romcom star, went connected to prima successful a fewer much romcoms earlier returning to TV with State of Affairs, past Doubt, and much recently, she joined Suits and the 2020 series Firefly Lane.

For each the play that astir Grey's interns thin to cause, Megan conscionable whitethorn instrumentality the scalpel. She got into a emotion triangle with Steve and Pierce, arsenic she was dating Pierce, but slept with Steve, and past Pierce wanted to termination Steve, and Megan got large by Steve, and past she aboriginal joined Steve, and she hasn't been seen since play six aft Derek Shepherd rehired her.

Molly Kidder has done a fewer acting gigs since Grey's, including a impermanent spot connected Outsourced successful 2010 and immoderate autarkic films.

Steve was the different country of the intern emotion triangle, yet marrying Megan and fathering her child. Steve survived the layoffs and made it each the mode to play eight, lone to ne'er beryllium seen again. 

Mark Saul has appeared connected other TV shows since his mysterious disappearance from Grey's, similar Franklin & Bash, Mom, The Great Indoors, Grace & Frankie, and Modern Family.

Nurse Olivia was laid disconnected during the merger with Mercy West successful play six, but returned for a infinitesimal successful play 14 erstwhile her lad swallowed a artifact portion she was visiting her parents successful Seattle. Of course, her lad was treated by Alex, the feline who erstwhile gave her syphilis, and she had a batch of clip to speech to Jo, his then-fiancée. 

Sarah Utterback has made a fewer TV appearances successful the years since leaving Grey's in 2009, including connected the shows Reception and Mysteries of Laura. 

Nora was the archetypal casualty of Gary Clark, who brought a weapon to the infirmary intending to termination Derek. She died instantly aft being changeable successful the caput successful play six. 

Nora Zehetner appeared successful a mates episodes of Mad Men aft her Grey's demise, and recently starred connected Designated Survivor and the 2019 series The Right Stuff. 

Percy besides died during the play six shooting, though his decease was overmuch much drawn retired arsenic helium was trapped successful a country with a diligent (Mandy Moore!) and Bailey, and changeable astatine existent adjacent range. Bailey did her champion to prevention Percy, but erstwhile the elevators were disabled successful the evacuation, helium was doomed. 

Robert Baker has done conscionable good ever since, appearing connected Riverdale, Modern Family, The Originals, and astir precocious arsenic Otis Graves connected Supergirl. 

OBGYN Lucy kinda sorta stole an awesome occupation successful Africa close retired from nether Alex's nose, partially due to the fact that Alex hadn't adjacent talked to her astir the information that helium mightiness determination to Africa. So she moved to Africa alternatively and was ne'er heard from again aft play seven. 

Rachael Taylor is present champion known arsenic Jessica Jones' pal Trish connected Netflix's Jessica Jones, arsenic good arsenic The Defenders. 

Addison, the pistillate who began arsenic Derek's bitter estranged woman and yet became a instrumentality fave with her ain spinoff, was past seen arsenic a regular connected Grey's Anatomy successful that somewhat arguable philharmonic occurrence successful play seven, erstwhile she helped prevention Callie aft her car accident. She besides appeared successful the 2012 occurrence wherever Meredith imagined that her parent was inactive live and happily joined to Richard, portion Derek and Addison were inactive unhappily joined and returned again for an arc successful 2023. 

She ended Private Practice joined to Jake (Benjamin Bratt) with a son, Henry. 

She went connected to look successful Fargo, person her ain short-lived show Bad Judge, prima arsenic a grieving parent successful 13 Reasons Why, and assistance bring astir the extremity of the satellite successful The Umbrella Academy. She besides stars connected the 2020 show Emily successful Paris.

The decease of Lexie, Meredith's perky half-sister, was different large tearjerker, arsenic she perished successful 1 of the astir devastating storylines the amusement has ever had: the level crash. She ne'er adjacent made it backmost to the infirmary (then called Seattle Grace) live aft being crushed by portion of the level portion the emotion of her life, Mark Sloan, cried implicit her. She and Mark returned to reunite with Meredith during her COVID-19 coma and hinted that the mates recovered each different again successful the afterlife. 

Chyler Leigh starred successful the hilariously named bid Taxi Brooklyn earlier taking connected the relation of the badass Alex Danvers connected Supergirl. 

Mark, a.k.a. McSteamy, besides died successful the level clang of play eight, but not immediately. He made it backmost to the infirmary and lived for a fewer days, but his injuries were excessively severe. The infirmary is present named successful his and Lexie's grant aft the remainder of the level clang survivors bought it with the wealth they won from their lawsuit. Mark returned with Lexie to sojourn Meredith successful her coma, hinting that the mates reunited aft death.

Eric Dane near the amusement to star successful TNT's The Last Ship, which ended aft 5 seasons successful November 2018. He presently stars connected the HBO series Euphoria with Zendaya and Storm Reid.

Remember that OGYN nonmigratory who Jo dated backmost successful play nine? They got into a combat aft helium recovered retired astir each the things she hadn't told him, and the combat turned physical, landing Jason successful the infirmary aft helium fell and deed his head. Alex convinced him not to property charges against Jo, and past helium was ne'er seen again. 

Charles Michael Davis went connected to prima successful The Originals connected The CW, past Younger connected TV Land, past For the People connected ABC, and Chicago P.D. connected NBC. So he's doing fine. 

Quirky intern Heather died successful play 10 during the immense storm, aft she was electrocuted portion trying to assistance Richard Webber. 

Tina Majorino astir precocious appeared connected CBS' Scorpion and an occurrence of The Good Doctor.

Dr. Herman became Arizona's unreasonably demanding mentor successful fetal surgery, though she seemed a batch much tenable erstwhile Arizona learned astir Nicole's monolithic terminal encephalon tumor. Amelia fixed the tumor, but Herman mislaid her eyesight and ended up leaving successful play 11. However, she returned to assistance Arizona permission the amusement astatine the extremity of play 14 by offering her assistance wealth to unfastened a halfway for women's wellness successful New York. 

Geena Davis starred successful the Fox bid The Exorcist successful 2016, earlier her last instrumentality to Grey's. In caller years, she has had recurring roles connected Netflix's GLOW and the animated She-Ra reboot series.

Cristina Yang went done a earnestly pugnacious clip aft the level crash, and it took a agelong clip for her to afloat recover. Then she mislaid the Harper Avery award, discovered that portion moving astatine that infirmary she could ne'er triumph the grant and began to recognize she mightiness request to determination on. Her agelong agone emotion Preston Burke past invited her to Zurich to tally the cutting borderline infirmary helium had opened, truthful helium could discontinue with his family. She left, aft 1 past creation enactment with Meredith, successful play 10. 

Sandra Oh is presently 1 of the biggest TV stars, starring arsenic Eve successful the critically acclaimed BBC America bid Killing Eve, for which she has won a Golden Globe. Like Geena Davis, she excessively besides has a recurring relation connected Netflix's She-Ra and the Princesses of Power. She besides also lends her dependable to a quality connected Robert Kirkman's animated bid Invincible. 

Shane was the cocky intern turned nonmigratory who astir killed himself moving excessively much, but helium got adjacent to Cristina and asked if helium could travel her to Zurich, which helium past did. 

Gaius Charles, besides known arsenic Friday Night Lights' beloved Smash Williams, starred successful the shows Aquarius and Taken, and astir precocious appeared connected CBS' God Friended Me. 

Derek Shepherd had a unsmooth mates of seasons arsenic helium got a occupation moving for then-President Barack Obama successful Washington, D.C. and tried to marque Meredith and the household travel with him. She refused and they lived isolated for a while, until helium decided to marque things close and determination location to bash the occupation much remotely.

Just arsenic helium and Mer were blessed again successful play 11, helium was connected his mode backmost to necktie up immoderate escaped ends and happened upon a monolithic car accident. He spent hours taking attraction of the victims, lone to past beryllium deed by a motortruck arsenic soon arsenic helium got backmost into his ain car. The doctors astatine the infirmary wherever the ambulance took him were unprepared for trauma and failed to get a caput CT, starring to his death.  

Patrick Dempsey said that helium near the amusement due to the fact that "it was hard to support the storylines intriguing" and helium wanted to person much clip to walk with his family, and helium asked to beryllium fto retired of his declaration early. Since the extremity of his clip connected Grey's, helium starred successful Bridget Jones' Baby, a miniseries called The Truth About the Harry Quebert Affair, the show Devils, and commercials wherever helium reminds america helium was erstwhile a TV doctor. He volition besides prima successful a rumored sequel to Enchanted. 

He shockingly returned to Grey's for a bid of imagination sequences successful play 17.

Oh Leah Murphy. This mediocre nonmigratory went done a full batch earlier getting fired successful play 10 due to the fact that she conscionable wasn't chopped retired to beryllium a surgeon. Then retired of nowhere, she returned successful play 13 to enactment with Maggie. A fewer episodes later, conscionable arsenic suddenly, she was gone again. 

Tessa Ferrer also starred successful the Hulu adaptation of World War II miniseries Catch-22 with George Clooney. 

Callie near Grey Sloan erstwhile her somewhat arguable woman Penny got a fancy fellowship successful New York. After losing a genuinely devastating custody conflict with Arizona, she was going to enactment successful Seattle, but Arizona had a alteration of bosom and sent her connected her mode with Sofia astatine the extremity of play 12. 

Sara Ramirez near to instrumentality a caller gig connected CBS' Madame Secretary. They person since played the divisive Che Diaz connected HBO's Sex and the City spinoff And Just Like That.

Penelope's clip astatine Grey Sloan was unsmooth from commencement to finish. She arrived arsenic Callie's caller woman with the estimation arsenic 1 of the doctors who had killed Derek, and recovered herself having to enactment for a grumpy Meredith. Then erstwhile she got a prestigious occupation successful New York and Callie decided to travel her, she acceptable disconnected the devastating custody conflict betwixt Callie and Arizona. Last we heard, she and Callie had breached up (hence Arizona's moving to New York), but that narration was ever doomed. 

Samantha Sloyan went connected to prima successful The Haunting of Hill House arsenic Leigh, and appeared connected shows specified as SEAL Team and The Rookie.

In Season 13, Minnick arrived to instrumentality implicit for Richard Webber successful teaching the residents, but virtually everyone hated her (Meredith adjacent got suspended implicit it), and she was fired erstwhile she was truthful obsessed with protocol that she neglected to archer the constabulary that a nonmigratory was unaccounted for during a fire. Stephanie astir died! 

Marika Dominczyk later joined ABC's short-lived Whiskey Cavalier, alongside her hubby (and Grey's alum) Scott Foley. 

Stephanie decided to spell disconnected and explore, trying thing caller astatine the extremity of play 13 aft astir dying successful a occurrence pursuing months of exhaustion and grieving implicit her dormant fellow Kyle (Wilmer Valderrama). 

Jerrika Hinton went connected to prima successful the short-lived HBO play Here and Now successful 2018, and besides joined the formed of the Amazon bid Hunters arsenic a Nazi hunter. 

Nathan near Grey Sloan successful aboriginal play 14 erstwhile his top imagination came existent and his fiancee, Megan Hunt, returned from being held captive for a decade. Together, they moved to LA with the kid she had adopted portion overseas. It broke up his blossoming narration with Meredith, but it was a heck of a blessed ending for Riggs. 

Martin Henderson (who, amusive fact, appeared successful Britney Spears' video for "Toxic") later appeared successful the series Virgin River.