Cuoco has been acting for astir of her life, notching her archetypal IMDb recognition astatine the property of 7 successful the precise intense-sounding 1992 TV movie Quicksand: No Escape. Which subsequently meant determination was nary escaping the cameras arsenic a teenager.

In 2002, Cuoco scored her breakout relation playing John Ritter's daughter on 8 Simple Rules, and The Young and the Restless actor Thad Luckinbill made for suitable reddish carpet limb candy.

A mates years aboriginal Cuoco was linked to future Gossip Girl actor Kevin Zegers aft they starred successful the spooky 2004 TV movie The Hollow together.

But whether determination was thing superior betwixt them oregon not, determination was thing but emotion erstwhile they reunited successful May 2022 at the John Ritter Foundation From the Heart LA Gala to honor the precocious histrion (who died abruptly successful 2003 during accumulation connected the 2nd play of 8 Simple Rules). Zegers had played Ritter's son in the 1999 TV movie It Came From the Sky.

"It's been 20 years since we archetypal met," Cuoco captioned a pic of her and Zegers, who shares 2 kids with woman Jaime Feld. "John Ritter was our surrogate Dad. So blessed to walk the nighttime unneurotic remembering our person and raising immoderate wealth for the @johnritterfoundation."

Thanks to a 12-season tally connected The Big Bang Theory that began successful 2007, countless fans person been invested successful Cuoco's happiness onscreen and off—though, ironically, Leonard-and-Penny shippers whitethorn not person realized they were rooting for two couples astatine once. 

"All the scenes up until we really got unneurotic successful existent life, it was evident determination was ever thing there," Cuoco recalled of her secret real-life romance with co-star Johnny Galecki, as quoted in Jessicas Radloff's recently released oral past of the deed CBS sitcom. "There was chemistry, and we were crushing connected each other. That was the full archetypal play until we really got unneurotic for real."

At Comic-Con, they'd unreal to accidental goodnight successful the edifice lobby with a affable hug, and then, Cuoco said, "we were similar small mice successful the night, moving backmost and distant to each other's rooms, trying not to beryllium noticed. I mean, who did we deliberation we were?"

Just a mates of colleagues who softly dated for astir 2 years—emphasis connected the quiet truthful arsenic to not disturb the delicate ecosystem of The Big Bang Theory universe. And Nobel Prizes for maturity all around, due to the fact that erstwhile Cuoco and Galecki exited each other's romanticist orbit, Penny and Leonard's chemistry wasn't affected successful the slightest.

"Johnny is really 1 of my champion friends," Cuoco told Andy Cohen on Watch What Happens Live in 2015. "It's a concern that ended well. I recognize sometimes it doesn't. It could person gone horrible."

Having successfully earned her master's successful privacy, Cuoco didn't up the personage mates ante erstwhile she started dating again—but astatine slightest radical knew she was retired and about.

And erstwhile Josh "Lazie" Resnik, an addiction counsellor and concisely the bassist for the metallic set Danzig, proposed successful October 2011, she said yes.

"The astonishment connection took spot during a quiescent day nighttime astatine home," her rep told People at the time. "The mates are precise blessed and excited to statesman readying their wedding."

They did not marque it retired of the readying stage, however, and successful March 2012 Cuoco confirmed she was no longer engaged.

Though attraction wasn't precisely unpaid to Cuoco arsenic her personage grew, she has said that nothing compared to the 10 days of 24/7 attention that came with her brief 2013 summer romance with Henry Cavill.

"I had nary 1 pursuing maine until I met Superman," she told Cosmopolitan in 2014. "I've been successful this concern for 20 years, and my full life, I could spell anywhere, bash anything. There had not been 1 paparazzi photograph of maine until similar respective months ago. The designation was crazy."

So perhaps scrutiny was their kryptonite.

Cuoco and Cavill returned to world successful July 2013. On New Year's Eve of that aforesaid year, Cuoco joined tennis subordinate Ryan Sweeting.

"I admit it happened fast, but that's who I am," she told Cosmo in 2014 of tying the knot aft hardly 5 months together. "When we met, I knew helium was the one."

He mightiness person been, but the feline helium turned into was not, and Cuoco announced successful September 2015 that they were divorcing. 

"I joined idiosyncratic the archetypal clip who wholly changed," she reflected to Cosmo in 2018. "The idiosyncratic I ended up with was not the idiosyncratic I primitively met. And that wasn't my fault—that was his."

Cuoco camouflaged the "12-31" commemorative wedding day tattoo connected her backmost with a larger illustration of a moth. "The value is, it was large capable to screen the numbers," she quipped to Ellen DeGeneres. 

Admittedly wary of matrimony but excited to beryllium successful emotion again, Cuoco was backmost successful the saddle again aft gathering competitory equestrian Karl Cook in early 2016.

"It's horses 24/7," she gushed to the New York Post in 2017 of their indispensable shared interest. "Most guys don't recognize wherefore you'd alternatively walk 10 hours successful your barn with your horse, successful s--t up to your knees, than travel sojourn them. But erstwhile you're a equine girl, that's it!"

They announced their engagement successful November 2017 and swapped vows on June 30, 2018. Though, interestingly enough, they continued to support abstracted households (they got joined astatine his equine ranch), which Cuoco acknowledged was an "unconventional" arrangement.

Their "separate lives" yet converged erstwhile the COVID-19 pandemic struck and they decided to determination successful together. "It's been large for our relationship," Cuoco said successful a distant quality connected Jimmy Kimmel Live successful 2020. "And we similar each other, we realized, which is adjacent better." 

But liking each different is lone fractional the battle. The pair confirmed Sept. 3, 2021, that they were splitting up. "Despite a heavy emotion and respect for 1 another, we person realized that our existent paths person taken america successful other directions," they said successful a associated statement. "We person some shared truthful overmuch of our travel publically truthful portion we would similar to support this facet of our idiosyncratic beingness private, we wanted to beryllium forthcoming successful our information together."

And past it was clip to spell backmost to enactment connected the 2nd play of The Flight Attendant.

"Going done my divorce, it was truly a ace acheronian time," Cuoco told Variety. "I conscionable didn't cognize however to woody with it. I was throwing myself into enactment to contradict my depression, and however upset I was. Unfortunately, the quality was truthful depressed that it wasn't helping me! I was really, really, truly struggling. A batch of tears."

In fact, the occurrence she submitted this twelvemonth to item her play 2 show for Emmy information featured an aggravated country that drew heavy from her ain emotional state astatine the time. Which wasn't needfully a steadfast thing, though she was nominated.

Used to powering done arsenic if everything was fine, this clip she couldn't fake it. "I've been precise unfastened astir it, due to the fact that I deliberation for the archetypal time, I wanted radical to cognize that things conscionable aren't ever what they seem," she said. "And things aren't ever truthful perfect. One period in, I had an involution connected myself successful my trailer—all my producers were successful there. And I said, 'I request help.'"

But then, arsenic Cuoco told E! News successful September, aft spending a batch of clip "kind of figuring myself out," she met Tom Pelphrey "and everything changed."

Set up by their shared manager, Andrea Pett-Joseph, they met astatine the Ozark last play premiere successful April and present they've got a girl connected the way. As they say, timing is everything.

"I don't adjacent look astatine him and say, 'Where person you been each my life? Why didn't I conscionable you sooner?'" Cuoco told USA Today in May. "I don't privation that, and helium doesn't either due to the fact that I had to spell done a batch of s--t and truly look astatine myself successful the reflector and the things that I person [messed up] implicit my past 10 years that I haven't dealt with."

She was "really not interested" successful getting joined again, she said, but was "at different signifier successful my beingness wherever I privation to person a heavy partnership. And it hits you similar a question and you're like, 'Whoa, I've ne'er had that.' I've ne'er gone heavy enough. I've ne'er faced my ain issues the mode that I person this past year. In the past 9 months, I've done a implicit 180. I don't deliberation this narration would beryllium what it is if I didn't spell done each of that."